Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Sonwu Supply CAS 755037-03-7 Pharmaceutical Powder Regorafenib |
CAS NO. | 755037-03-7 |
MF | C21h15clf4n4o3 |
MW | 482.82 |
Appearance | White Powder |
Certificate | ISO, SGS, GMP, HACCP |
Assay Method | HPLC |
Extraction Type | Solvent Extraction |
Sample | Available |
MOQ | 5g |
Shelf life | 2 Years |
Storage | Store in cool & dry place not freeze Keep away from strong light and heat |
1. Regorafenib targets both bad cell proliferation and disease vasculature through inhibition of receptors of tyrosine kinases (VEGFR, KIT, RET, FGFR, and PDGFR) and serine/threonine kinases (Raf and p38MAPK). Regorafenib suppresses growth of human Hep3B, PLC/PRF/5 and HepG2 cells in a concentration- and time-dependent manner.
2. Regorafenib reveals potent dose-dependent TGI in various preclinical human xenograft models in mice, with bad cell shrinkages in breast MDA-MB-231 and renal 786-O carcinoma models. Regorafenib prevents not only the growth of syngeneic primary 4T1 breast cells growing orthotopically in the fat pad, but also suppresses the formation of bad cell metastasis in the lung.
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