| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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| Name | Sonwu Supply CAS 877399-52-5 Crizotinib Powder Crizotinib |
| CAS NO. | 877399-52-5 |
| Molecular Formula | C21h22cl2fn5o |
| Purity | 99% |
| Appearance | Off-white Powder |
| Certificate | ISO, SGS, GMP, HACCP |
| Assay Method | HPLC |
| Sample | Available |
| MOQ | 5g |
| Shelf life | 2 Years |
| Storage | Store in cool & dry place not freeze Keep away from strong light and heat |
Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET.
Recommended product collocation
an important target for serious disease chemotherapy.
The two can be used together.
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