Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Sonwu Supply Purity Canertinib Intermediate Canertinib |
CAS NO. | 267243-28-7 |
MF | C24h25clfn5o3 |
MW | 485.94 |
Melting Point | 188-190° |
Boiling Point | 691.0±55.0 °C(Predicted) |
Density | 1.355±0.06 g/cm3(Predicted) |
Appearance | White Powder |
Certificate | ISO, SGS, GMP, HACCP |
Assay Method | HPLC |
Extraction Type | Solvent Extraction |
Sample | Available |
MOQ | 5g |
Shelf life | 2 Years |
Storage | Store in cool & dry place not freeze Keep away from strong light and heat |
Canertinib is an irreversible quinazoline-based inhibitor of HER family tyrosine kinases with IC50 values of 0.8, 19 and 7 nM for EGFR, HER2 and HER4, respectively.Canertinib irreversibly binds into the ATP pocket within the TK domain of all erbB family members, where the side-chain at position C6 of canertinib is brought into close proximity with cysteines of erbB members, followed by the rapid formation of a covalent bond, which permanently inactivates the catalytically active erB1, erB2 and erB4 family members and effectively inhibits erbB3-dependent signaling.
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