Powder: | Yes |
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Customized: | Customized |
Certification: | GMP, HSE, ISO 9001, USP, BP, SGS |
Suitable for: | Adult |
State: | Powder |
Purity: | 99% |
Samples: |
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Customization: |
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Name | Sonwu Supply Powder Material Crizotinib |
CAS NO. | 877399-52-5 |
Molecular Formula | C21h22cl2fn5o |
Purity | 99% |
Appearance | White Powder |
Certificate | ISO, SGS, GMP, HACCP |
Assay Method | HPLC |
Extraction Type | Solvent Extraction |
Sample | Available |
MOQ | 5g |
Shelf life | 2 Years |
Storage | Store in cool & dry place not freeze Keep away from strong light and heat |
Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, and Recepteur d'Origine Nantais (RON). Translocations can affect the ALK gene resulting in the expression of oncogenic fusion proteins; it is also a potent inhibitor of ALK phosphorylation and signal transduction. This inhibition is associated with G1-S phase cell cycle arrest and induction of apoptosis in positive cells in vitro and in vivo. Crizotinib also inhibits the related ROS1 receptor tyrosine kinase.
Crizotinib is an anti-bad cells product acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma.
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