| Customization: | Available |
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| Certification: | RoHS, BRC, ISO, FDA, HACCP, SGS |
| Assay Method: | HPLC |
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Backuchiol is a meroterpene (a chemical compound having a partial terpenoid structure) in the class terpenophenol.
It was first isolated in 1966 by Mehta et al. from Psoralea corylifolia seed and was called Bakuchiol based on the Sanskrit name of the plant, Bakuchi. Bakuchiol is a meroterpene phenol abundant in and mainly obtained from the seeds of the Psoralea corylifolia plant, which is widely used in Indian as well as in Traditional Chinese medicine to treat a variety of diseases. It has also been isolated from other plants, such as P. grandulosa, P. drupaceae,Ulmus davidiana, Otholobium pubescens,Piper longum and Aerva sangulnolenta Blum.
Even though the first complete synthesis of Bakuchiol has been described in 1973, its first commercial use in topical applications did not occur until 2007 when it was introduced to the market under the trade name Sytenol A by Sytheon Ltd.
It has been reported to have anticancer activity in preclinical models, possibly due to its structural similarity with resveratrol. One study in rats suggested that bakuchiol and ethanol extracts of the Chinese medicinal plant Psoralea corylifolia could protect against bone loss.
Bakuchiol possesses antioxidant, anti-inflammatory and anti-bacterial properties. Bakuchiol isolated from P. corylifolia has shown activity against numerous Gram-positive and Gram-negative oral pathogens. It was able to inhibit the growth of Streptococcus mutans under a range of sucrose concentrations, pH values and in the presence of organic acids in a temperature-dependent manner and also inhibited the growth of cells adhered to a glass surface.
Despite having no structural resemblance to retinol, Bakuchiol was found to have retinol functionality through retinol-like regulation of gene expression. In 2018, a randomized, double-blind, 12-week clinical study with 44 volunteers demonstrated that Bakuchiol is comparable with retinol in its ability to improve photo-aging (wrinkles, hyperpigmentation) but has a better skin tolerance.
Bakuchiol has been found to possess antiandrogenic activity in prostate cancer cells, which inhibited cell proliferation.
A small number of trials have investigated bakuchiol and its benefits. Some studies suggest that bakuchiol can help lessen the appearance of fine lines and wrinkles, as well as address hyperpigmentation in the skin.
That said, Dr. Hollmig points out that this study did not compare bakuchiol with a retinoid, so it would not be a fair to say that bakuchiol is as effective as a prescription-strength product.
It's important to point out that this study was done on only 13 people, so more research is needed to fully understand how effective bakuchiol is in treating acne and how it compares with retinoids, which are commonly recommended to treat mild to moderate acne.
In a nutshell, the research on bakuchiol so far seems promising, but more studies are needed. "It's difficult to quantify the exact benefits on the skin because studies have either been performed in vitro, meaning not on human skin but in a lab, or have been performed without perfect study design, which makes drawing firm conclusions difficult."
In addition, the skin-care industry has funded much of the current research on bakuchiol, and so there is a risk of bias in this research, he says.
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HARD CAPSULE
Type: 0# 1# 2# 3# Coulor: More than 30 colours are available. Capsules have a hard shell, and either contain powders or dry ingredients. Suitable for all kinds of plant extract powder. |
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TABLET
Type: 250mg 500mg 1000mg 2000mg Professional Mould, Provide you tablets of various shapes. Tablets are a harder dosage form compared to softgels and capsules. Suitable for all kinds of plant extract powder. |
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SOFTGEL
Softgels have a gelatin shell, surrounding a gel or liquid interior.Suitable for all kinds of animal and plant essential oils. |
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BOTTLE
Volume:60cc,120cc, 150cc, 200cc, 250cc...
Customized size,color and label design are available. |
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SMALL BAG PACKAGE Type: 10g, 50g, 100g, 500g, 1000g, 2000g... Small bag is also a good choice for a small amount of contents packaged.Customized size,color and label design are available. |
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