| Customization: | Available |
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| Certification: | RoHS, BRC, ISO, FDA, HACCP, SGS |
| Assay Method: | HPLC |
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Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (Tanacetum parthenium), after which it is named, and in the closely related tansy (Tanacetum vulgare).[1] It is found in highest concentration in the flowers and fruit. Parthenolide's molecular structure depiction is often incorrect regarding the stereochemistry of the epoxide, although X-ray single crystal structures are available.
Parthenolide has a variety of reported in vitro biological activities, including:
Inhibition of HDAC1 protein without affecting other class I/II HDACs, which leads to sustained DNA damage response in certain cells (required for apoptosis).
Modulation of the NF-κB-mediated inflammatory responses in experimental atherosclerosis.
Inducing apoptosis in acute myelogenous leukemia (AML) cells, leaving normal bone marrow cells relatively unscathed. Moreover, the compound may get at the root of the disease because it also kills stem cells that give rise to AML.
Activity against Leishmania amazonensis.
Microtubule-interfering activity.
Agonist of the adiponectin receptor 2 (AdipoR2).
Inhibition of mammalian thioredoxin reductase
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HARD CAPSULE
Type: 0# 1# 2# 3# Coulor: More than 30 colours are available. Capsules have a hard shell, and either contain powders or dry ingredients. Suitable for all kinds of plant extract powder. |
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TABLET
Type: 250mg 500mg 1000mg 2000mg Professional Mould, Provide you tablets of various shapes. Tablets are a harder dosage form compared to softgels and capsules. Suitable for all kinds of plant extract powder. |
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SOFTGEL
Softgels have a gelatin shell, surrounding a gel or liquid interior.Suitable for all kinds of animal and plant essential oils. |
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BOTTLE
Volume:60cc,120cc, 150cc, 200cc, 250cc...
Customized size,color and label design are available. |
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SMALL BAG PACKAGE Type: 10g, 50g, 100g, 500g, 1000g, 2000g... Small bag is also a good choice for a small amount of contents packaged.Customized size,color and label design are available. |
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