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Agomelatine - another blockbuster drug in the psychiatric category.
Agomelatine, a melatonin analogue, was both the first melatonin receptor agonist and 5-hydroxytryptamine 2C(S-HTX) receptor antagonist. Animal experiments and clinical studies showed that the drug had the effects of anti-depression, anti-anxiety, adjusting sleep rhythm and regulating biological clock, and its adverse reactions were few, and there was no adverse effect on sexual function, and no withdrawal reaction was observed.
A large number of animal experiments have proved that agomelatine has the effects of anti-depression, anti-anxiety and regulating the rhythm of sleep cycle.
Other studies have suggested that the mechanism of agomelatine against depression may be related to the increase of neuronal plasticity and neuronal hyperplasia in the hippocampus.
N-Methyl-D-aspartic acid(NMDA) | Alpga GPC | Phenibut | Aniracetam |
Piracetam | Pramiracetam | Coluracetam | Fasoracetam |
PRL-8-53 | NSI-189 | J-147 | Compound 7P |
Sunifiram | Tianeptine | 9-Methyl-9H-beta-carboline | Magnesium L-Threonate |