Product Description
Product Name |
Compound 7P |
CAS No. |
1890208-58-8 |
Molecular Formula |
C22H23N3O5S |
Molecular Weight |
441.508 |
Grade Standard |
Medicine Grade |
Purity |
99%min |
5. What is Compound 7P?
Compound 7P promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, Compound 7P was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of Compound 7P translates into stimulation of axon regeneration in vivo.
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Function
Compound 7p was developed as one in series of compounds with the aim of identifying dual-acting thromboxane receptor antagonist/synthase inhibitors . In fact compound 7p shows selectivity for prostaglandin I2 synthase (PTGIS , CYP8A1) over thromboxane synthase (CYP5A1) .
Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways
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