Product Description
Product Name |
ABT-199 |
MF |
C45H50ClN7O7S |
Molecular mass |
868.44 |
CAS |
1257044-40-8 |
Appearance |
White Powder |
MOQ |
100g |
Shelf Life |
2 years |
ABT-199, also known as venetoclax used for the chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line used for CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets.
Certifications

Application
1. ABT-199 is used for certain types of cytopathic disease, particularly chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It is classified as a B-cell lymphoma-2 (BCL-2) inhibitor, which means it works by blocking the activity of the BCL-2 protein that helps cytopathic disease cells survive.
2. ABT-199 may be used alone or in combination with other chemotherapy agents, and has demonstrated promising results in clinical trials for the CLL and SLL.
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Rituximab + ABT-199:
Rituximab targets CD20 on the surface of B-cell lymphocytes, which are the cells involved in the development of CLL and SLL. The combination of ABT-199 with rituximab has shown improved outcomes in clinical studies, including higher response rates and longer progression-free survival compared to ABT-199 alone.
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