| Powder: | Yes |
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| Customized: | Customized |
| Certification: | GMP, HSE, ISO 9001, USP, BP |
| Suitable for: | Elderly, Adult |
| State: | Powder |
| Purity: | >99% |
| Samples: |
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| Customization: |
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Sonwu supply 1076-38-6 Esomeprazole magnesium
| Product name | Esomeprazole magnesium |
| Appearance | White crystalline powder |
| M F | 2(C17H18N3O3S)2.Mg |
| EINECS | 627-029-7 |
| CAS No. | 1076-38-6 |
| Specification | 99% |
| MW | 713.12 |
| Mol | 161973-10-0.mol |
Esomeprazole is the latest in the class of agents called the protonpump inhibitors(PPIs). These inhibit gastric secretion by binding to hydrogen- potassium adenosinetriphosphatase (H+, K+-ATPase) in gastric parietal cells. In addition, these agents have been shown to be effectively used for the Zollinger-Ellison syndrome and Barrett's esophagus. Esomeprazole is the fourth PPI to be approved for use in the United States, following omeprazole; the other available PPIs are lansoprazole, pantoprazole, and rabeprazole. PPIs have similar chemical structures and a shared mechanism of action. Esomeprazole, the S-isomer of omeprazole, is the first PPI developed as a single optical isomer. Esomeprazole has an improved pharmacokinetic profile over omeprazole (a racemic mixture of Sand Roptical isomers), resulting in more potent acid suppression.
Esomeprazole, like the other PPIs, does this by accumulating in the secretory canaliculus of the parietal cell when the cell is secreting After accumulating in this acidic environment, these agents are converted to a tetracyclic sulfenamide, which binds covalently to sulfhydryl groups of H+, K+-ATPase, rendering it inactive. The enzyme's inactivation blocks the final step of secretion into the stomach, resulting in a higher gastric pH. The covalent binding of PPIs to H+, K+-ATPase is irreversible; restoration of gastric acid production depends on the rate of de novo proton-pump regeneration, not how long plasma levels are maintained.
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