| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Larotinib is an inhibitor of tropomyosin receptor kinase (Trk), TrkA, TrkB and trkC. TrkA, B and C are encoded by genes ntrk1, NTRK2 and ntrk3. They can produce a chimeric Trk fusion protein that can be activated. The protein can be used as a carcinogenic driver to promote cell proliferation and survival in harmful cell lines. Larotinib shows its activity in cells with constitutive activation of Trk protein, deletion of protein regulatory domain or overexpression of Trk protein caused by gene fusion
| item | Loxo 195 |
| Place of Origin | China;Shaanxi |
| Grade | Food and Pharmaceutical Grade |
| MOQ | 10g |
| CAS | 1350884-56-8 |
| Sample | Avaliable |
| Shelf Life | 2 Years |
Recommended product collocation
Bothe Larotrectinib (LOXO-101) and Loxo 195 are ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C)
| AZD9291 | Lapatinib ditosylate | Lapatinib | Gefitinib |
| Niraparib | Imatinib mesylate | Imatinib | LOXO 101 |
| Ibrutinib | Cabozantinib Malate | baricitinib | Erlotinib Hydrochloride |
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